教務長 - 嘉南藥理大學教務處

洪瑞祥

姓名：洪瑞祥 Jui-Hsaing Hung

現職：教授兼副校長兼教務長兼生物科技系主任

分機：1101

服務單位：生物科技系

E-mail：hung86@mail.cnu.edu.tw

學歷：

1.成功大學基礎醫學研究所博士

2.陽明大學醫學生物技術研究所碩士

3.文化大學食品營養系學士

經歷：

嘉南藥理大學教授兼副校長(113年2月~)

嘉南藥理大學教授兼教務長 (111年8月~迄今)

嘉南藥理大學教授兼通識教育中心主任(111年8月~113年1月)

嘉南藥理大學教授兼副教務長 (110年8月~111年 7月)

嘉南藥理大學教授兼教學資源中心主任 (109年02月~111年07月)

嘉南藥理大學生物科技系包裝材料檢測實驗室主管(102年8月~103年8月~)

嘉南藥理科技大學生物科技系主任(111年2月~迄今)

嘉南藥理大學生物科技系教授 (108年8月~迄今 )

嘉南藥理大學生物科技系副教授 (101年8月~108年7月 )

嘉南藥理大學生物科技系助理教授 (97年8月~101年7月)

美國南加州大學及堪薩斯州大學訪問學者 (98年1月~98年6月)

嘉南藥理科技大學生物科技系 (97年10月~迄今)

美國俄亥俄州立大學藥學系博士後研究 (95年08月~97年06月)

研究領域：

1.內質網壓力在疾病和腫瘤細胞的關係

2.生物資訊

3.細胞與訊息傳遞對於基因調控之影響

期刊著作：

1. Hung, J.H., Su IJ, Lei HY, Wang HC, Lin WC, Chang WT, Huang Wenya, Chang WC, Chang YS, Chen CC, and Lai MD. Endoplasmic Reticulum Stress Stimulates the Expression of Cyclooxygenase-2 through Activation of NF-κB and pp38 Mitogenactivated Protein Kinase. J Biol Chem 2004, 279: 46384-46392.

2. Lu, Y. S., Kashida Y., Kulp, S.K., Wang, Y.C., Hung, J.H., Tang, M., Lin, Z.Z., Chen, D.J., Cheng, A.L., Chen, C.S. Efficacy of A Novel Histone Deacetylase Inhibitor in Murine Models of Hepatocellular Carcinoma. Hepatology 2007, 46: 1119-1130.

3. Hung, J.H., Lu, Y.S., Wang, Y.C., Ma, Y.H., Wang, D., Kulp, S.K., Muthusamy, N., Byrd, J.C., Cheng, A.L., Chen, C.S. FTY720 Induces Apoptosis in Hepatocellular Carcinoma Cells through Activation of Protein Kinase C Signaling. Cancer Research 2008, 68: 1204-1212.

4. Wang, Y.C., Kulp, S.K., Wang, D., Yang, C.C., Sargeant, A.M., Hung, J.H., Kashida, Y., Yamaguchi, M., Chang, G.D. and Chen, C.S. Targeting ER-stress and Akt Signaling with OSU-03012 and Gefitinib or Erlotinib to Overcome Epidermal Growth Factor Receptor Inhibitor-resistance in Non-small Cell Lung Cancer Cells with Activated Akt. Cancer Research 2008, 68: 2820-2830.

5. Hung JH, Yan CW, Su IJ, Wang HC, Lei HY, Lin WC, Chang WT, Huang W, Lu TJ, and Lai MD . Hepatitis B virus large surface protein interacts with acid alpha-glucosidase and alters glycogen metabolism. Hepatology Research 2010, 40: 633-640.

6. Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology 2011, 53: 1943-1958.

7. Sanchez JF, Entwistle R, Hung JH, Yaegashi J, Jain S, Chiang YM, Wang CC, Oakley BR.Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans. J Am Chem Soc 2011, 133: 4010-4017.

8. Chang YS, Tsai CT, Huangfu CA, Huang WY, Lei HY, Lin CF, Su IJ, Chang WT, Wu PH, Chen YT, Hung JH, Young KC, Lai MD. ACSL3 and GSK-3β are essential for lipid upregulation induced by endoplasmic reticulum stress in liver cells. J Cell Biochem 2011, 112: 881-893.

9. Hung JH*, Teng YN, Wang HC, Su IJ, Wang CC, Huang WY, Lee KH, Lu KY, Wang LH. Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. PLoS One 2011, 6: e28977.

10. Lo HC, Entwistle R, Guo CJ, Ahuja M, Szewczyk E, Hung JH, Chiang YM, Oakley BR, Wang CC. Two Separate Gene Clusters Encode the Biosynthetic Pathway for the Meroterpenoids Austinol and Dehydroaustinol in Aspergillus nidulans. J Am Chem Soc 2012, 134: 4709-4720.

11. Lin WC, Chuang YC, Chang YS, Lai MD, Teng YN, Su IJ, Wang CC, Lee KH, and Hung JH*. Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation. PLoS One 2012, 7: e39120.

12. Lee KH, Wu CJ, Wang CC, JH Hung*. Prevention of chronic HBV infection induced hepatocellular carcinoma development by using antiplatelet drugs. Hepatobiliary Surg Nutr 1:15, 2012.

13. Lee KH, Ho WY, Wu SJ, Omar HA, Huang PJ, Wang CC, Hung JH*. Modulation of cyclins, p53 and mitogen-activated protein kinases signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. Int J Mol Sci 2014, 15: 743-757.

14.Lee KH, Ho WY, Wu SJ, Cheng TL, Huang PJ, Wang CC, Hung JH*. Behaviorselective apoptotic capacity of 4-(3,4,5-Trimethoxyphenoxy) benzoic acid and its methyl derivatives on two breast cancer cell lines. Anticancer Res 2014, 34: 1801-1809.

15. Cheng TL, Lai CH, Jiang SJ, Hung JH, Liu SK, Chang BI, Shi GY, Wu HL. RHBDL2 is a critical membrane protease for anoikis resistance in human malignant epithelial cells. Scientific World Journal 2014, 2014: 902987.

16. Cheng TL, Chen PS, Li RH, Yuan SS, Su IJ, Hung JH*. Induction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells. Int J Mol Sci 2014, 15: 12442-12457.

17. Shen KH, Liao AC, Hung JH, Lee WJ, Hu KC, Lin PT, Liao RF, Chen PS. αSolanine inhibits invasion of human prostate cancer cell by suppressing epithelialmesenchymal transition and MMPs expression. Molecules 2014, 19: 11896-11914. 18. Tsai YC, Teng YN, Hung JH, Wu CH, Kuo YT, Kuo PL, Chiu CC, Huang B. Correlation between leucine rich domain and the stability of LRWD1 protein in human NT2/D1 cells. Adv Med Sci 2014, 59: 266-272.

19. Induction of Cytotoxicity by Manila Palm Seed Extracts in Hepatocellular Carcinoma Cells. Kuan Han Lee, Hui Ping Tang, Shiaw Wei Tyan, Kun Hsiang Liu, Jui Hsiang Hung*. CHIA-NAN ANNUAL BULLETIN 2014, 40: 1-8.

20. Wu JJ, Omar HA, Lee YR, Teng YN, Chen PS, Chen YC, Huang HS, Lee KH, Hung JH*. 6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms. Eur J Pharmacol 2015, 762: 449-458.

21. Jui-Hsiang Hung, Chia-Yun Chen, Hany A. Omar, Kuo-Yuan Huang, Che-Chia Tsao, Chien-Chih Chiu, Yi-Ling Chen, Po-Han Chen, Yen-Ni Teng. Reactive Oxygen Species Mediate Terbufos-Induced Apoptosis in Mouse Testicular Cell Lines via the Modulation of Cell Cycle and Pro-Apoptotic Proteins. Environ Toxicol. 2016, 31: 1888-1898.

22. Omar HA*, Tolba MF, Hung JH, Al-Tel TH. OSU-2S/Sorafenib Synergistic Antitumor Combination against Hepatocellular Carcinoma: The Role of PKCδ/p53. Front Pharmacol 2016, 7: 463.

23. Shen KH, Hung JH, Chang CW, Weng YT, Wu MJ, Chen PS*. Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression. Chem Biol Interact 2017, 268: 129-135. (共同第一作者)

24. Wang CY, Li CY, Hsu HP, Cho CY, Yen MC, Weng TY, Chen WC, Hung YH, Lee KT, Hung JH, Chen YL, Lai MD. PSMB5 plays a dual role in cancer development and immunosuppression. Am J Cancer Res. 2017, 7: 2103-2120.

25. Chen SY, Lee YR, Hsieh MC, Omar HA, Teng YN, Lin CY, Hung JH. Enhancing the Anticancer Activity of Antrodia cinnamomea in Hepatocellular Carcinoma Cells via Cocultivation With Ginger: The Impact on Cancer Cell Survival Pathways. Front Pharmacol. 2018, 9: 780.

26. Hung JH, Wee SK, Omar HA, Su CH, Chen HY, Chen PS, Chiu CC, Wu MS, Teng YN. Nuclear factor erythroid-2-related factor regulates LRWD1 expression and cellular adaptation to oxidative stress in human embryonal carcinoma cells. Biochimie. 2018, 148: 99-106.

27. Wu WD, Chen PS, Omar HA, Arafa EA, Pan HW, Jeng J, Hung JH. Antrodia cinnamomea boosts the anti-tumor activity of sorafenib in xenograft models of human hepatocellular carcinoma. Sci Rep. 2018, 8: 12914.

28. Kuo YT, Lin CC, Kuo HT, Hung JH, Liu CH, Jassey A, Yen MH, Wu SJ, Lin LT. Identification of baicalin from Bofutsushosan and Daisaikoto as a potent inducer of glucose uptake and modulator of insulin signaling-associated pathways. J Food Drug Anal. 2019, 27: 240-248.

29. Wang CF, Wang WN, Kuo SW, Chiang YW, Hung JH, Lee KJ. Biocompatible Meshes with Appropriate Wettabilities for Underwater Oil Transportation/Collection and Highly Effective Oil/Water Separation. Langmuir. 2018, 34: 11442-11448.

30. Wu PS, Yen JH, Wang CY, Chen PY, Hung JH, Wu MJ. 8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells.

Biomedicines. 2020, 8: 506.

31. Shen KH, Hung JH, Liao YC, Tsai ST, Wu MJ, Chen PS. Sinomenine Inhibits Migration and Invasion of Human Lung Cancer Cell through Downregulating Expression of miR-21 and MMPs. Int J Mol Sci. 2020, 21: 3080

32. Chen HL, Gong JY, Lin SC, Li S, Chiang YC, Hung JH, Yen CC, Lin CC. Effects of Sclareol Against Small Cell Lung Carcinoma and the Related Mechanism: In Vitro and In Vivo Studies. Anticancer Res. 2020, 40: 4947-4960.

33. Lin YY, Wang CY, Phan NN, Chiao CC, Li CY, Sun Z, Hung JH, Chen YL, Yen MC, Weng TY, Hsu HP, Lai MD. PODXL2 maintains cellular stemness and promotes breast cancer development through the Rac1/Akt pathway. Int J Med Sci. 2020, 17: 1639-1651.

34. Lin WL, Hung JH, Huang W. Association of the Hepatitis B Virus Large Surface Protein with Viral Infectivity and Endoplasmic Reticulum Stress-mediated Liver Carcinogenesis. Cells. 2020, 9: 2052.

35. Wang CY, Chiao CC, Phan NN, Li CY, Sun ZD, Jiang JZ, Hung JH, Chen YL, Yen MC, Weng TY, Chen WC, Hsu HP, Lai MD. Gene signatures and potential therapeutic targets of amino acid metabolism in estrogen receptor-positive breast cancer. Am J Cancer Res. 2020, 10: 95-113.

36. Liu HL, Yeh IJ, Phan NN, Wu YH, Yen MC, Hung JH, Chiao CC, Chen CF, Sun Z, Jiang JZ, Hsu HP, Wang CY, Lai MD. Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short- and long-term models. Infect Genet Evol. 2020, 85: 104438.

37. Wu YH, Yeh IJ, Phan NN, Yen MC, Hung JH, Chiao CC, Chen CF, Sun Z, Hsu HP, Wang CY, Lai MD. Gene signatures and potential therapeutic targets of Middle East respiratory syndrome coronavirus (MERS-CoV)-infected human lung adenocarcinoma epithelial cells. J Microbiol Immunol Infect. 2021, 26: S1684-1182(21)00058-X.

38. Hung JH, Cheng HY, Tsai YC, Pan HA, Omar HA, Chiu CC, Su YM, Lin YM, Teng YN. LRWD1 expression is regulated through DNA methylation in human testicular embryonal carcinoma cells. Basic Clin Androl. 2021, 31: 12.

39. Cheng LC, Kao TJ, Phan NN, Chiao CC, Yen MC, Chen CF, Hung JH, Jiang JZ, Sun Z, Wang CY, Hsu HP.Novel signaling pathways regulate SARS-CoV and SARS-CoV-2 infectious disease. Medicine (Baltimore). 2021, 100: e24321.

40. Chen PS, Hsu HP, Phan NN, Yen MC, Chen FW, Liu YW, Lin FP, Feng SY, Cheng TL, Yeh PH, Omar HA, Sun Z, Jiang JZ, Chan YS, Lai MD, Wang CY, Hung JH. CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer. Aging (Albany NY). 2021, 13: 4157-4181.